Development of Therapies for Celiac Disease
March 20-21, 2014
Host Celiac Disease Center at Columbia University, New York
A scientific program designed for those interested in the development of non-dietary therapies for celiac disease.
Presentation Summaries in RED
- Introduction Peter Green, MD
- Immune pathogenesis of celiac disease Ludwig Sollid - Norway
Discussed the concept of the important role of Tg2 specific B cells amplifying the anti Tg2 T cell raising the possibility that celiac disease is the disease of B cell over amplification.
The immune response to wheat proteins Paul Ciclitira - UK (Moderator)
- Nutritional quality of seed storage proteins Joachim Messing - USA
- The major storage proteins in seeds/grains are call prolamins – high in proline and glutamin amino acids. The ratio of protein to carbohydrate varies in seed families.
- New methods are being used to sequence wheat cultivars and identify new gliadins that may be important in celiac disease.
- Wheat gluten and celiac disease - an evolutionary collision Donald Kasarda – USA
- Reviewed the primary structure of wheat glutenins and gliadins in wheat. Reported the research review which indicates no increase of gluten in wheat over the past 100 years.
- Immune response to glutenin and other grains in celiac disease Paul Ciclitira - UK
- Emphasized the gliadins and the glutenins are both important in the toxicity level of wheat in those with celiac disease.
- Wheat amylase-trypsin inhibitors: their role in celiac disease and beyond. Detlef Schuppan - Germany
- Reported his discovery of the wheat amaylase tripson inhibitor as a non-gluten protein that can stimulate the innate immune system and potentially be responsible for Non-Celiac Wheat Sensitivity.
- Immune response to non gluten proteins Armin Alaedini, PhD -- USA
- Identifying many other non gluten proteins and determining that only a few seem to be able to evoke an immune reaction in those with celiac disease.
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